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39 for urbanicity (Vassos et al. A single mutation in a candidate gene is unlikely to have a big impact in the population, by taking the aggregate effect of all mutations; however, we can differentiate people being at high genetic risk for disease.

A polygenic architecture for psychiatric disorders of many weakly contributing variants means that genetic effects interact on the scale of disease (i.affected v. not affected) but act more additively on a susceptibility to disease scale (i.